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Best trans-Resveratrol featuring ResVinol-25

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Doctors Best

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Product Details Best trans-Resveratrol 200 features ResVinol-25�, a proprietary extract providing concentrated levels of polyphenols and trans-resveratrol from red wine matrix and the root of the Japanese knotweed (Polygonum cuspidatum) plant. Resveratrol exists in both trans- and cis-forms. However, published research suggests that only the trans- form has valuable biological activity. ResVinol-25� is a high-quality extract subjected to rigorous ProfileProven� analytical and quality assurance procedures designed to ensure potency and purity of the extract from batch to batch. The product is extensively tested for heavy metals, bacterial and fungal contaminants, and pesticides to verify purity and compliance with acceptable standards.

Product Benefits

* Science-based nutrition. * Dietary supplement. * High-potency resveratrol formulation. A summary report on resveratrol noted that its ability to modulate immune function and promote a balanced inflammatory response works not through one simple mechanism, but through several complex pathways.2 As shown in mice, resveratrol inhibited the TNF-alpha cytokine pathways that are critical in regulation of immune cells. Resveratrol can inhibit inflammatory enzymes and the synthesis of pro-inflammatory mediators and eicosanoids.3-5 In mouse mast cells, resveratrol inhibited TNF-alpha and histamine release, in turn blocking production of unfavorable eicosanoids. In lung cells, resveratrol appears to inhibit macrophage release of IL-8 chemokines in vitro, limiting overreaction of white blood cells.6 An in vitro study conducted with human polymorphonuclear leukocytes (or PMN-L, a type of white blood cell) showed that even tiny amounts of resveratrol specifically inhibited the formation of pro-inflammatory metabolites of arachidonic acid.7 The �French Paradox� has led to extensive research into the physiological effects of the bioactive components of red wine�the active ingredients in Best trans-Resveratrol. To build on evidence of the potent cardiovascular effects of resveratrol seen in animal studies, the focus has now shifted to working with human samples. In 20 healthy adults examined before and after 15 days of controlled wine consumption, an increase in blood nitric oxide (NO) production was reported.8 Nitric oxide is a gas responsible for signaling the smooth muscle in blood vessels to relax, thus promoting healthy circulatory function. In a particularly convincing study using blood vessel tissue derived from humans, resveratrol promoted nitric oxide-induced vascular relaxation and overall enhanced endothelial (blood vessel) function.9 Lastly, it should be mentioned that a good deal of interest has been generated by the apparently favorable actions of resveratrol on glucose metabolism, as seen in animal studies.21,22 A recent in vitro study demonstrated trans-resveratrol�s influence on how skeletal muscle responds to glucose, presumably through the action of sirtuins.23 Furthermore, a 2010 in vitro resveratrol study even shows positive metabolic interactions with human fat cells.24 While the implications of results like these are provoking, clinical trials need to be conducted to determine the degree of practicality for such uses of resveratrol.

Ingredients

Supplement Facts
Serving Size: 1 capsule
Amount per Serving	Potency	% Daily Value
trans-Resveratrol	200 mg	+
Polyphenols (from red wine matrix (Grape (Vitis vinifera)) and Japanese Knotweed (Polygonum cuspidatum))	80 mg	+
+ Daily Value not established.
Other Ingredients: Rice flour, silicon dioxide, magnesium stearate (vegetable source).

Dosage

Take 1 or more capsules daily with meals.

Extra Info

Does Not Contain: milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, salt, or preservatives.

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California Proposition 65 WARNING: Some products on this website contains progesterone, a chemical known to the State of California to cause cancer. Consult with your physician before using this product.