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SAMe 400 mg

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Life Extension

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Product Details
SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways. SAMe occurs naturally in the body. It is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways. SAMe facilitates glutathione usage and maintains acetylcholine levels, which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration. SAMe levels may become depleted from sickness and age. Supplementation with the cofactors folate, trimethylglycine (TMG or betaine), vitamins B6 and B12, together with SAMe appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid, and is used in the brain to make the neurotransmitter acetylcholine.

Product Benefits

In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage. Methylation (contributing methyl groups to activate certain molecules) The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.) Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals).

Ingredients

Supplement Facts
Serving Size: 1 tablet
Amount per Serving	Potency
S-Adenosyl-Methionine	400 mg
Other Ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, silica, stearic acid, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, titanium dioxide, yellow ochre.

Dosage

Take one tablet two to three times daily in divided doses, preferably on an empty stomach. Take with co-factors vitamins B12, B6, and folic acid.

Extra Info

Contains trace amounts of corn.

Warning

SAMe should not be taken by those diagnosed with bipolar disorder. Keep Out of Reach of Children. Do not Exceed Recommended Dose. Do not purchase if the outer seal is broken or damaged. When using the nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

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